Fig. 1 · Structure
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Tegeprotafib
PTPN1/2 Inhibitor
Tegeprotafib is a potent inhibitor of protein tyrosine phosphatases PTPN1 and PTPN2, exhibiting IC50 values of 4.4 nM and 1-10 nM, respectively. This compound demonstrates significant biological activity in modulating cellular signaling pathways, making it a valuable tool for research in cancer and metabolic disorders. Tegeprotafib is suitable for studies focused on the therapeutic targeting of phosphatase pathways to investigate their roles in disease mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2407610-46-0 |
| Applications | PTPN1/2 Inhibitor |
| Formula | C13H11FN2O5S |
| Molecular Weight | 326.30 |
| Synonyms | PTPN2/1-IN-1 |
| SMILES | O=C1NS(=O)(N(C1)C2=C(F)C3=CC(OC)=CC=C3C=C2O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.