Fig. 1 · Structure
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Telocinobufagin
Anticancer Agent
Telocinobufagin is a potent bufadienolide that targets and inhibits key signaling pathways including STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail, and PLK1, contributing to its antitumor activity against a variety of cancers such as non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer, and head and neck squamous cell carcinoma. Its ability to induce tumor cell apoptosis further enhances its therapeutic potential. Additionally, Telocinobufagin modulates the immune response, enhances Th1 activity, and exhibits cardiac stimulation by inhibiting Na+/K+-ATPase. Its analgesic properties make it relevant in acute pain research, showcasing a diverse range of biological activities for potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 472-26-4 |
| Applications | Anticancer Agent |
| Formula | C24H34O5 |
| Molecular Weight | 402.52 |
| Synonyms | Telobufotoxin; Telocinobufogenin |
| SMILES | O[C@@]([C@@]1(CC2)C)(CC[C@@H]1C(C=C3)=COC3=O)[C@@](CC[C@@]45O)([H])[C@@]2([H])[C@]4(CC[C@H](O)C5)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.