Temozolomide-d3 is a deuterium-labeled derivative of Temozolomide, a potent oral DNA alkylating agent that effectively penetrates the blood-brain barrier. This compound exerts proautophagic and proapoptotic effects, demonstrating significant cytotoxicity against tumor cells with deficient O6-alkylguanine DNA alkyltransferase (OGAT) and intact mismatch repair mechanisms. Additionally, Temozolomide exhibits both antitumor and antiangiogenic activities, making it valuable for research in cancer therapy and mechanisms of chemoresistance.
Temozolomide-d3 is a deuterium-labeled derivative of Temozolomide, a potent oral DNA alkylating agent that effectively penetrates the blood-brain barrier. This compound exerts proautophagic and proapoptotic effects, demonstrating significant cytotoxicity against tumor cells with deficient O6-alkylguanine DNA alkyltransferase (OGAT) and intact mismatch repair mechanisms. Additionally, Temozolomide exhibits both antitumor and antiangiogenic activities, making it valuable for research in cancer therapy and mechanisms of chemoresistance.
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