TEPP-46

Catalog No.: A16279

PKM2 activator

TEPP-46

TEPP-46 Chemical Structure

CAS NO. 1221186-53-3

TEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$400.00
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Biological Activity

TEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR.
In vitro DMSO 73 mg/mL (195.99 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.85 mL 134.24 mL 268.49 mL
0.5 mM 5.37 mL 26.85 mL 53.7 mL
1 mM 2.68 mL 13.42 mL 26.85 mL
5 mM 0.54 mL 2.68 mL 5.37 mL

*The above data is based on the productmolecular weight 372.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16279
Actions Activator
CAS No. 1221186-53-3
Formula C17H16N4O2S2
M. Wt 372.46
Purity >98%
Synonyms ML-265
SMILES O=C1C(N(C)C2=C3SC(S(C)=O)=C2)=C3C=NN1CC4=CC=CC(N)=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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