Terrecyclic Acid is a sesquiterpene derived from the fungal species Aspergillus terreus. This compound exhibits notable antibiotic and anticancer properties, demonstrating activity against Staphylococcus aureus, Bacillus subtilis, and Micromonospora roseus with minimum inhibitory concentrations of 25, 50, and 25 μg/mL, respectively. Additionally, terrecyclic acid induces a heat shock response, elevates reactive oxygen species (ROS) levels, and suppresses NF-κB activity and cellular proliferation in 3T3-Y9-B12 cells. In vivo studies reveal that terrecyclic acid effectively reduces ascitic fluid tumor cell counts in a mouse model of P388 murine leukemia at concentrations of 0.1, 1, and 10 mg/mL.
Terrecyclic Acid is a sesquiterpene derived from the fungal species Aspergillus terreus. This compound exhibits notable antibiotic and anticancer properties, demonstrating activity against Staphylococcus aureus, Bacillus subtilis, and Micromonospora roseus with minimum inhibitory concentrations of 25, 50, and 25 μg/mL, respectively. Additionally, terrecyclic acid induces a heat shock response, elevates reactive oxygen species (ROS) levels, and suppresses NF-κB activity and cellular proliferation in 3T3-Y9-B12 cells. In vivo studies reveal that terrecyclic acid effectively reduces ascitic fluid tumor cell counts in a mouse model of P388 murine leukemia at concentrations of 0.1, 1, and 10 mg/mL.
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