Fig. 1 · Structure
Documents & Downloads
Tetrahydromethotrexate
Folic Acid Antagonist
Tetrahydromethotrexate is a potent folate antagonist that exhibits enhanced inhibitory activity compared to Methotrexate. This compound has demonstrated effectiveness against specific bacterial strains, including Streptococcus faecalis and Pediococcus erevisiae, as well as significant efficacy in various animal models. It is primarily utilized in research focused on cancer and autoimmune diseases, making it an important reagent for understanding therapeutic mechanisms and developing new treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 4299-28-9 |
| Applications | Folic Acid Antagonist |
| Formula | C20H26N8O5 |
| Molecular Weight | 458.47 |
| SMILES | O=C(CC[C@H](NC(C1=CC=C(C=C1)N(C)CC2NC3=C(N=C(N=C3NC2)N)N)=O)C(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.