Fig. 1 · Structure
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Tetrahydropteroylpentaglutamate
10-CHO-THF Dehydrogenase Inhibitor
Tetrahydropteroylpentaglutamate is a potent inhibitor of 10-CHO-THF dehydrogenase, exhibiting a dissociation constant (Kd) of 20 nM. This compound functions by forming an irreversible complex with the enzyme, thereby effectively inhibiting its activity. Tetrahydropteroylpentaglutamate is valuable for research applications focused on folate metabolism, as well as studies investigating the biochemical pathways influenced by 10-CHO-THF.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 41520-73-4 |
| Applications | 10-CHO-THF Dehydrogenase Inhibitor |
| Formula | C39H51N11O18 |
| Molecular Weight | 961.89 |
| Synonyms | H4PteGlu5 |
| SMILES | O=C1C2=C(NC(N)=N1)NCC(N2)CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.