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Tetrakis(hydroxymethyl)phosphonium sulfate

Protein Crosslinker

Tetrakis(hydroxymethyl)phosphonium sulfate is a potent protein crosslinker that facilitates the formation of stable covalent bonds with primary and secondary amines found in amino acids and proteins through a Mannich-type reaction. This reagent is widely utilized in the development and modification of hydrogels, particularly enhancing gelation times and storage modulus in recombinant elastin-like protein systems. Additionally, it demonstrates excellent cytocompatibility, promoting the growth and differentiation of embryonic and neural stem cells within three-dimensional encapsulated environments, making it ideal for cell encapsulation applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	55566-30-8
Applications	Protein Crosslinker
Formula	C₄H₁₂O₄P·1/2SO₄
Molecular Weight	406.28
SMILES	O=S([O-])([O-])=O.OC[P+](CO)(CO)CO

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.