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Tezusomant

Catalog No.: A60573
Growth Hormone Receptor Antagonist
Tezusomant is a growth hormone receptor antagonist that effectively inhibits the activity of growth hormone. This compound is instrumental in investigating conditions related to excessive growth hormone secretion, such as acromegaly and related endocrine disorders. Tezusomant facilitates research aimed at understanding the underlying mechanisms of these diseases and exploring potential therapeutic interventions.
Tezusomant 2802416-72-2 Growth Hormone Receptor Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTezusomant is a growth hormone receptor antagonist that effectively inhibits the activity of growth hormone. This compound is instrumental in investigating conditions related to excessive growth hormone secretion, such as acromegaly and related endocrine disorders. Tezusomant facilitates research aimed at understanding the underlying mechanisms of these diseases and exploring potential therapeutic interventions.
Product Information
Catalog NumA60573
FormulaC120H171N23O32S
Molecular Weight2479.84
CAS Number2802416-72-2
Sequence{N-sulfanylacetyl-Phe(p-COOH)}-{Lys(Me)}-Val-Val-Ser-Asn-{Trp(CH2CO)}-{Phe(p-COOH)}-Lys-{Trp(OH)}-{Aib}-Val-Ala-{Lys(NH2)}-gGlu-{gGlu(C16 diacid)} (covalent bridge:Lys2-Trp7; sulfide bridge:Phe1-Ala13)
Sequence shortening{N-sulfanylacetyl-Phe(p-COOH)}-{Lys(Me)}-VVSNW-{Trp(CH2CO)}-{Phe(p-COOH)}-K-{Trp(OH)}-{Aib}-VA-{Lys(NH2)}-gGlu-{gGlu(C16 diacid)} (covalent bridge:Lys2-Trp7; sulfide bridge:Phe1-Ala13)
SMILESO=C1[C@@]2(CC=3C=4C(N(C3)CC(=O)NCCCC[C@](N(C)C(=O)[C@H](CC5=CC=C(C(O)=O)C=C5)NC(=O)CSC[C@@H](C(NCCCC[C@H](NC(CC[C@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(N)=O)=O)NC(=O)[C@H]([C@H](C)C)NC(=O)C(C)(C)NC(=O)[C@H](CC=6C=7C(NC6)=CC=C(O)C7)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC8=CC=C(C(O)=O)C=C8)N1)(C(=O)N[C@@H]([C@@H](C)C)C(=O)N[C@@H]([C@H](C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N2)[H])=CC=CC4)[H]
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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GPCR/G Protein > GHSR