Fig. 1 · Structure
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TFAM activator 1
TFAM Activator
TFAM Activator 1 is a potent activator of Transcription Factor A, Mitochondrial (TFAM), which plays a critical role in mitochondrial biogenesis. This compound exhibits anti-inflammatory properties and promotes the restoration of mitochondrial function by increasing TFAM protein levels and mitochondrial DNA (mtDNA) copy number. Additionally, TFAM Activator 1 mitigates mtDNA stress-induced inflammatory responses, reducing the production of pro-inflammatory cytokines such as TNF-α, CXCL-10, and IFN. It is a valuable reagent for research into mitochondrial dysfunction associated with neurodegenerative diseases, including Parkinson’s and Alzheimer’s.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 932992-44-4 |
| Applications | TFAM Activator |
| Formula | C18H19N3O4S |
| Molecular Weight | 373.43 |
| SMILES | CN1C(OC2=CC(S(=O)(N3CCC(CC3)C4=CC=NC=C4)=O)=CC=C21)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.