TFAP2β modulator-1

Catalog No.: A31454
TFAP2β Modulator
TFAP2β modulator-1 is a potent modulator of the transcription factor TFAP2β, promoting its condensation through the induction of conformational changes within its intrinsically disordered region. This compound exhibits significant anti-tumor activity by inducing apoptosis in esophageal squamous cell carcinoma (ESCC) cells, as well as in relevant mouse models and organoids. TFAP2β modulator-1 serves as a valuable tool for investigating the role of TFAP2β in ESCC research and therapeutic development.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
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Nature Volume 622 Issue 7982 (2023)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionTFAP2β modulator-1 is a potent modulator of the transcription factor TFAP2β, promoting its condensation through the induction of conformational changes within its intrinsically disordered region. This compound exhibits significant anti-tumor activity by inducing apoptosis in esophageal squamous cell carcinoma (ESCC) cells, as well as in relevant mouse models and organoids. TFAP2β modulator-1 serves as a valuable tool for investigating the role of TFAP2β in ESCC research and therapeutic development.
Product Information
Catalog NumA31454
FormulaC17H11Cl2N3O
Molecular Weight344.19
CAS Number668435-69-6
SMILESClC(C1=C(N(C2=O)C)C=CC(Cl)=C1)=C2C3=NC4=CC=CC=C4N3
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