Fig. 1 · Structure
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TFB-TBOA
Glutamate Transporter Bocker
TFB-TBOA is a potent blocker of glutamate transporters, specifically targeting EAAT1, EAAT2, and EAAT3. It demonstrates competitive inhibition with IC50 values of 22 nM for EAAT1, 17 nM for EAAT2, and 300 nM for EAAT3, effectively suppressing their transport activity. This compound is valuable for research applications investigating glutamate signaling and transporter function in neurobiology and related fields.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 480439-73-4 |
| Applications | Glutamate Transporter Bocker |
| Formula | C19H17F3N2O6 |
| Molecular Weight | 426.34 |
| Synonyms | CF3-Bza-TBOA |
| SMILES | O=C(C1=CC=C(C=C1)C(F)(F)F)NC2=CC(CO[C@H](C(O)=O)[C@H](N)C(O)=O)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.