TG-101348 (Fedratinib, SAR302503)

Catalog No.: A11082

JAK2/FLT3 inhibitor

TG-101348 (Fedratinib, SAR302503)

TG-101348 (Fedratinib, SAR302503) Chemical Structure

CAS NO. 936091-26-8

TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.

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5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $100.00

Special Price $80.00

50 mg

Regular Price: $320.00

Special Price $256.00

100 mg

Regular Price: $580.00

Special Price $464.00

10mM * 1mL in DMSO

Regular Price: $122.00

Special Price $97.60

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Biological Activity

TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.
Targets
JAK2 (Cell-free assay) JAK2 (V617F) (Cell-free assay) FLT3 (Cell-free assay) RET (Cell-free assay)
3 nM3 nM15 nM48 nM
In vitro DMSO 90 mg/mL (171.53 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.06 mL 95.29 mL 190.59 mL
0.5 mM 3.81 mL 19.06 mL 38.12 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
5 mM 0.38 mL 1.91 mL 3.81 mL

*The above data is based on the productmolecular weight 524.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11082
Actions Inhibitor
CAS No. 936091-26-8
Formula C27H36N6O3S
M. Wt 524.7
Purity >98%
Synonyms SAR302503,TG101348,TG101348
SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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