TG-101348 (Fedratinib, SAR302503)

Catalog No.: A11082

JAK2 inhibitor

TG-101348 (Fedratinib, SAR302503)

TG-101348 (Fedratinib, SAR302503) Chemical Structure

CAS NO. 936091-26-8

TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $100.00

Special Price $80.00

50 mg

Regular Price: $320.00

Special Price $256.00

100 mg

Regular Price: $580.00

Special Price $464.00

10mM * 1mL in DMSO
$122.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity.
Targets
JAK2 (Cell-free assay) JAK2 (V617F) (Cell-free assay) FLT3 (Cell-free assay) RET (Cell-free assay)
3 nM3 nM15 nM48 nM
In vitro (25°C) DMSO 100 mg/mL (190.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.06 mL 95.29 mL 190.59 mL
0.5 mM 3.81 mL 19.06 mL 38.12 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
5 mM 0.38 mL 1.91 mL 3.81 mL

*The above data is based on the productmolecular weight 524.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11082
Actions Inhibitor
M. Wt 524.7
Formula C27H36N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936091-26-8
Synonyms SAR302503,TG101348,TG101348
SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

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