Fig. 1 · Structure
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TGFβRII-IN-3
TGFβ RII Degrader
TGFβRII-IN-3 is a selective degrader of the TGFβ type II receptor (TGFβ RII), exhibiting an IC50 of 4.1 μM. This compound disrupts TGFβ signaling pathways by promoting the proteolytic degradation of TGFβ RII, leading to the inhibition of endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 is a valuable tool in cancer research, offering insights into the modulation of TGFβ-mediated biological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2351149-20-5 |
| Applications | TGFβ RII Degrader |
| Formula | C27H27F3N2O2 |
| Molecular Weight | 468.51 |
| SMILES | O=C(N(CC1=CC=CC(C2=CC=C(C(F)(F)F)C=C2)=C1)C)C3=C(C)NC4=C3C(CC(C)(C4)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.