Fig. 1 · Structure
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TGN-020
AQP4 Inhibitor
TGN-020 is a selective inhibitor of Aquaporin 4 (AQP4) with an IC50 of 3.1 μM, serving as a valuable tool in chemical biology. This compound is designed for investigating the role of AQP4 in various physiological and pathological processes. TGN-020 has demonstrated efficacy in reducing edema and inhibiting glial scar formation following spinal cord compression injuries in animal models, making it a potential candidate for research into therapeutic strategies for neurological damage.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 51987-99-6 |
| Applications | AQP4 Inhibitor |
| Formula | C8H6N4OS |
| Molecular Weight | 206.23 |
| SMILES | O=C(C1=CC=CN=C1)NC2=NN=CS2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.