TGX-221
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
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Adooq Products cited in reputable paper
Adooq's TGX-221 has been cited by 4 publications
- Kevin J Pridham, .et al. , iScience, 2024, May 7;27(6):109921 PMID: 38812542
- Mostafa Khater, .et al. , J Biol Chem, 2021, Jan-Jun, 296:100805 PMID: 34022220
- Mostafa Khater, .et al. , J Biol Chem, 2021, Jan 22;296:100325 PMID: 33493514
- Pridham KJ, .et al. , Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Biological Activity
| Description | TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β. | |||||
|---|---|---|---|---|---|---|
| Targets |
| |||||
| Cell Research |
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Product Information
| Catalog Num | A10923 |
|---|---|
| Formula | C21H24N4O2 |
| Molecular Weight | 364.4 |
| CAS Number | 663619-89-4 |
| SMILES | CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4 |
| Synonyms | TGX221 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 11 mg/mL (30.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.44 mL | 137.21 mL | 274.42 mL |
| 0.5 mM | 5.49 mL | 27.44 mL | 54.88 mL |
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
