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PI3K Inhibitor

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Catalog No. A10923

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TGX-221 5mg A10923-5
TGX-221 10mg A10923-10
TGX-221 25mg A10923-25
TGX-221 100mg A10923-100
TGX-221 10mM * 1mL in DMSO A10923-10mM-D
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.


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Publications citing Adooq Products
TGX-221 Citations (1)
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Chemical Information

Catalog Num A10923
Actions Inhibitor
M. Wt 364.4
Formula C21H24N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 663619-89-4
Synonyms TGX221

Biological Activity

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
Target Value
p110βIC50: 5nM
p110δIC50: 0.1μM
p110αIC50: 5μM
p110γIC50: >10μM
C2αIC50: >10μM
PI4KIC50: >10μM
AblIC50: >10μM
EGFRIC50: >10μM
FynIC50: >10μM
HER2IC50: >10μM
Insulin ReceptorIC50: >10μM
CaseinKinase2IC50: >10μM
CDK2/CyclinAIC50: >10μM
ERK1IC50: >10μM
p38αIC50: >10μM
p70S6KIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
CaMKIC50: >10μM


Solubility (25°C) * In vitro DMSO 12 mg/mL (32.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.21 mL 274.42mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

*The above data is based on the productmolecular weight 364.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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