TGX-221

Catalog No.: A10923

PI3K Inhibitor

TGX-221

TGX-221 Chemical Structure

CAS NO. 663619-89-4

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $75.00

Special Price $60.00

25 mg

Regular Price: $150.00

Special Price $120.00

100 mg

Regular Price: $250.00

Special Price $200.00

10mM * 1mL in DMSO
$92.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
Targets
Target Value
p110βIC50: 5nM
p110δIC50: 0.1μM
p110αIC50: 5μM
p110γIC50: >10μM
C2αIC50: >10μM
PI4KIC50: >10μM
AblIC50: >10μM
EGFRIC50: >10μM
FynIC50: >10μM
HER2IC50: >10μM
Insulin ReceptorIC50: >10μM
CaseinKinase2IC50: >10μM
CDK2/CyclinAIC50: >10μM
ERK1IC50: >10μM
p38αIC50: >10μM
p70S6KIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
CaMKIC50: >10μM
In vitro (25°C) DMSO 12 mg/mL (32.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.21 mL 274.42 mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

*The above data is based on the productmolecular weight 364.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10923
Actions Inhibitor
M. Wt 364.4
Formula C21H24N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 663619-89-4
Synonyms TGX221
SMILES CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4

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