Catalog No.: A10923

PI3K Inhibitor


TGX-221 Chemical Structure

CAS NO. 663619-89-4

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.

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5 mg
10 mg
25 mg
100 mg
10mM * 1mL in DMSO
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  • Mostafa Khater, .et al. Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK, J Biol Chem, 2021, Jan-Jun, 296:100805 PMID: 34022220
  • Mostafa Khater, .et al. G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers, J Biol Chem, 2021, Jan 22;296:100325 PMID: 33493514
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Biological Activity

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
Target Value
p110βIC50: 5nM
p110δIC50: 0.1μM
p110αIC50: 5μM
p110γIC50: >10μM
C2αIC50: >10μM
PI4KIC50: >10μM
AblIC50: >10μM
EGFRIC50: >10μM
FynIC50: >10μM
HER2IC50: >10μM
Insulin ReceptorIC50: >10μM
CaseinKinase2IC50: >10μM
CDK2/CyclinAIC50: >10μM
ERK1IC50: >10μM
p38αIC50: >10μM
p70S6KIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
CaMKIC50: >10μM
In vitro (25°C) DMSO 11 mg/mL (30.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.21 mL 274.42 mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

*The above data is based on the productmolecular weight 364.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10923
Actions Inhibitor
CAS No. 663619-89-4
Formula C21H24N4O2
M. Wt 364.4
Purity >98%
Synonyms TGX221

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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