TH-Z816

Catalog No.: A24269
KRAS(G12D) inhibitor
TH-Z816 is a reversible inhibitor targeting the KRAS^G12D mutation, with an IC50 value of 14 μM. It is a useful tool for cancer research, particularly in studies involving KRAS^G12D-driven tumorigenesis.
Grouped product items
Size Price Stock Qty
1mg
$72.00
In stock
5mg
$216.00
In stock
10mg
$368.00
In stock
50mg
$1,104.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTH-Z816 is a reversible inhibitor targeting the KRAS^G12D mutation, with an IC50 value of 14 μM. It is a useful tool for cancer research, particularly in studies involving KRAS^G12D-driven tumorigenesis.
Product Information
Catalog NumA24269
FormulaC29H38N6O
Molecular Weight486.65
CAS Number2847881-42-7
SMILESC[C@H]1N(CCNC1)C2=C3C(CN(C4=CC=CC5=C4C(C)=CC=C5)CC3)=NC(OC[C@H]6N(CCC6)C)=N2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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