TH-Z827

Name: TH-Z827
Brand: Adooq Bioscience
SKU: A63550
Rating: 5 (288 reviews)

Catalog No.: A63550

KRAS(G12D) Inhibitor

TH-Z827 is a selective inhibitor of the KRAS(G12D) mutant, demonstrating an IC50 of 2.4 μM. This compound does not interact with wild-type KRAS or the KRAS(G12C) variant. TH-Z827 effectively disrupts the interaction between KRAS(G12D) and CRAF, with an IC50 value of 42 μM, making it a valuable tool for studying KRAS-driven cancers and developing targeted therapies.

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TH-Z827 2847881-81-4 KRAS(G12D) Inhibitor

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Grouped product items
Size	Price	Stock
5mg	$475.00	In stock
10mg	$790.00	In stock
25mg	$1,580.00	In stock
50mg	$2,460.00	In stock
100mg	$3,360.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	TH-Z827 is a selective inhibitor of the KRAS(G12D) mutant, demonstrating an IC50 of 2.4 μM. This compound does not interact with wild-type KRAS or the KRAS(G12C) variant. TH-Z827 effectively disrupts the interaction between KRAS(G12D) and CRAF, with an IC50 value of 42 μM, making it a valuable tool for studying KRAS-driven cancers and developing targeted therapies.

Product Information

Catalog Num	A63550
Formula	C30H38N6O
Molecular Weight	498.66
CAS Number	2847881-81-4
SMILES	CN(CCC1)[C@@H]1COC2=NC(N3[C@@H]4CNC[C@H]3CC4)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2

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