TH-Z835

Name: TH-Z835
Brand: Adooq Bioscience
SKU: A24546
Rating: 5 (288 reviews)

Catalog No.: A24546

KRAS G12D inhibitor

TH-Z835 is a mutant-selective KRAS^G12D inhibitor with an IC₅₀ of 1.6 μM. It inhibits both mantGMPPNP/GPPNP and GPPNP/mantGMPPNP nucleotide exchange, effectively targeting KRAS^G12D activation and signaling.

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TH-Z835 2766209-50-9 KRAS G12D inhibitor

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Grouped product items
Size	Price	Stock
1mg	$198.00	In stock
5mg	$594.00	In stock
10mg	$1,012.00	In stock
50mg	$3,036.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	TH-Z835 is a mutant-selective KRAS^G12D inhibitor with an IC₅₀ of 1.6 μM. It inhibits both mantGMPPNP/GPPNP and GPPNP/mantGMPPNP nucleotide exchange, effectively targeting KRAS^G12D activation and signaling.

Product Information

Catalog Num	A24546
Formula	C30H38N6O
Molecular Weight	498.66
CAS Number	2766209-50-9
SMILES	CN(CCC1)[C@@H]1COC2=NC(N3C[C@H]4N[C@H](CC4)C3)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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