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TH10184

Ligand for NUDT5

TH10184 is a selective inhibitor of NUDT5, a critical enzyme involved in nucleotide metabolism. This compound exhibits the ability to modulate NUDT5 activity, making it a valuable tool for exploring cellular pathways regulated by this target. Additionally, TH10184 can be conjugated with VH032 and a suitable linker to synthesize the PROTAC NUDT5 degrader DDD2, facilitating targeted protein degradation studies. Its applications are vital for research in cellular and molecular biology, particularly in the context of cancer and other diseases related to nucleotide regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2271044-59-6
Applications	Ligand for NUDT5
Formula	C₂₂H₂₆N₈O₄
Molecular Weight	466.49
SMILES	COC(C=C1C(O2)=NN=C2CN3C(C(N(C(N4C)=O)C)=O)=C4N=C3N5CCNCC5)=C(C=C1)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.