Fig. 1 · Structure
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TH1217
dCTPase Inhibitor
TH1217 is a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrating an IC50 of 47 nM. This compound enhances the cytotoxic effects of cytidine analogues in leukemia cells, making it valuable for cancer research. Additionally, TH1217 has been identified to modulate SARS-CoV-2 interactors, indicating potential applications in studies related to COVID-19.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1862212-48-3 |
| Applications | dCTPase Inhibitor |
| Formula | C20H17BCl2N4O6 |
| Molecular Weight | 491.09 |
| Synonyms | ZINC1775962367 |
| SMILES | CC1=NC2=C(C(Cl)=C(Cl)C=C2N1CC3=CC=C(C=C3)[B-]45OC(C[N+]4(C)CC(O5)=O)=O)[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.