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Thailanstatin B

Pre-mRNA Splicing Inhibitor

Thailanstatin B is a potent inhibitor of pre-mRNA splicing, exhibiting an IC50 value of 6.18 μM. This compound demonstrates significant antiproliferative activity, making it a valuable tool for studying the mechanisms underlying gene expression and cancer biology. Its ability to modulate splicing processes positions Thailanstatin B as an important reagent in RNA research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1426953-23-2
Applications	Pre-mRNA Splicing Inhibitor
Formula	C₂₈H₄₂ClNO₉
Molecular Weight	572.09
SMILES	C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C\[C@H](C)OC(C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2[C@H]([C@@](O)(C[C@H](O2)CC(O)=O)CCl)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.