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Thailanstatin D

AR-V7 mRNA Inhibitor

Thailanstatin D is a potent AR-V7 mRNA inhibitor that disrupts the interaction between U2AF65 and SAP155, preventing their binding to the polypyrimidine tract crucial for gene splicing. This compound demonstrates significant anti-tumor activity in human castration-resistant prostate cancer (CRPC) xenografts, promoting cellular apoptosis. Thailanstatin D is a valuable tool for studying AR-V7 mediated pathways and could have important implications in cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1609105-89-6
Applications	AR-V7 mRNA Inhibitor
Formula	C₂₈H₄₁NO₈
Molecular Weight	519.63
SMILES	C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C\[C@H](C)OC(C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(C[C@H](O2)CC(O)=O)CO3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.