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Thalidomide-4-C3-NH2 hydrochloride

Ligand for E3 Ligase

Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived ligand that targets cereblon, an E3 ubiquitin ligase. This compound is instrumental in the recruitment of CRBN protein, facilitating the development of PROTACs through linkers connecting the ligand to specific proteins. Thalidomide-4-C3-NH2 hydrochloride is valuable in studies related to targeted protein degradation and therapeutic development in cancer and autoimmune disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2357110-84-8
Applications	Ligand for E3 Ligase
Formula	C₁₆H₁₈ClN₃O₄
Molecular Weight	351.78
SMILES	O=C1NC(C(CC1)N2C(C3=CC=C(CCCN)C=C3C2=O)=O)=O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.