Fig. 1 · Structure
Documents & Downloads
Thalidomide 4'-ether-PEG1-azide
Ligands for E3 Ligase
Thalidomide 4'-ether-PEG1-azide is a Thalidomide-derived ligand that specifically targets cereblon (CRBN), facilitating its recruitment for protein degradation. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) to enhance targeted protein removal in cellular systems. Its unique structure promotes effective binding and functional interactions in E3 ligase-mediated pathways, supporting studies in protein regulation and therapeutic discovery.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2758432-02-7 |
| Applications | Ligands for E3 Ligase |
| Formula | C17H17N5O6 |
| Molecular Weight | 387.35 |
| SMILES | [N-]=[N+]=NCCOCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.