Thalidomide-4-NH-PEG1-COO(t-Bu) functions as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound features a t-Bu protecting group, which can be cleaved under acidic conditions, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a crucial intermediate in the development of CRBN-based PROTAC molecules, facilitating targeted protein degradation for research applications in cancer and other diseases.
Thalidomide-4-NH-PEG1-COO(t-Bu) functions as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound features a t-Bu protecting group, which can be cleaved under acidic conditions, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a crucial intermediate in the development of CRBN-based PROTAC molecules, facilitating targeted protein degradation for research applications in cancer and other diseases.
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