Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified derivative of Thalidomide that serves as a ligand for the E3 ubiquitin ligase, Cereblon (CRBN). This compound is integral in PROTAC (proteolysis-targeting chimera) synthesis, allowing for efficient recruitment of CRBN to target proteins for degradation. The Boc protecting group can be removed under acidic conditions, facilitating further chemical modifications required in PROTAC development. Thalidomide-4-NH-PEG1-NH-Boc is an essential intermediate for researchers exploring targeted protein degradation and related therapeutic strategies.
Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified derivative of Thalidomide that serves as a ligand for the E3 ubiquitin ligase, Cereblon (CRBN). This compound is integral in PROTAC (proteolysis-targeting chimera) synthesis, allowing for efficient recruitment of CRBN to target proteins for degradation. The Boc protecting group can be removed under acidic conditions, facilitating further chemical modifications required in PROTAC development. Thalidomide-4-NH-PEG1-NH-Boc is an essential intermediate for researchers exploring targeted protein degradation and related therapeutic strategies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
