Thalidomide-4-NH-PEG2-COO(t-Bu) is a thalidomide derivative that serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). The t-Bu protecting group can be cleaved under acidic conditions, facilitating its incorporation into PROTAC (Proteolysis Targeting Chimera) synthesis. This compound is essential for research involving targeted protein degradation and the development of CRBN-based PROTAC molecules.
Thalidomide-4-NH-PEG2-COO(t-Bu) is a thalidomide derivative that serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). The t-Bu protecting group can be cleaved under acidic conditions, facilitating its incorporation into PROTAC (Proteolysis Targeting Chimera) synthesis. This compound is essential for research involving targeted protein degradation and the development of CRBN-based PROTAC molecules.
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