Fig. 1 · Structure
Documents & Downloads
Thalidomide-4-O-CH2-COO(t-Bu)
Ligands for E3 Ligase
Thalidomide-4-O-CH2-COO(t-Bu) is a modified form of Thalidomide that serves as a ligand for the E3 ligase Cereblon (CRBN). It effectively recruits CRBN proteins, facilitating profound biological activity associated with protein degradation pathways. The tert-butyl protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC molecules. This compound is essential for researchers working on CRBN-based PROTAC development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1950635-36-5 |
| Applications | Ligands for E3 Ligase |
| Formula | C19H20N2O7 |
| Molecular Weight | 388.37 |
| SMILES | O=C1N(C2C(NC(CC2)=O)=O)C(C3=C1C(OCC(OC(C)(C)C)=O)=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.