Fig. 1 · Structure
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Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride
Cereblon Ligand
Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride acts as a functionalized cereblon ligand, primarily utilized in PROTAC (proteolysis-targeting chimeras) research and development. It features a terminal amine, enabling easy conjugation to target protein ligands, thereby facilitating targeted degradation of specific proteins in cellular assays. This compound supports investigations into targeted protein degradation mechanisms and contributes to the advancement of therapeutic strategies in various disease models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2564466-93-7 |
| Applications | Cereblon Ligand |
| Formula | C25H35ClN4O9 |
| Molecular Weight | 571.02 |
| SMILES | O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCOCCOCCOCCCN.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.