Fig. 1 · Structure
Documents & Downloads
Thalidomide-5,6-F
Ligand for E3 Ligase
Thalidomide-5,6-F is a Thalidomide-derived ligand that selectively targets cereblon (CRBN), facilitating its recruitment for the targeted degradation of specific proteins via the ubiquitin-proteasome pathway. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), enabling innovative approaches in the research of targeted protein degradation, drug discovery, and therapeutic interventions. Its unique mechanism offers valuable insights into cellular regulation and disease processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1496997-41-1 |
| Applications | Ligand for E3 Ligase |
| Formula | C13H8F2N2O4 |
| Molecular Weight | 294.21 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(F)C(F)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.