Fig. 1 · Structure
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Thalidomide-5-Br,6-F
E3 Ligase Activator
Thalidomide-5-Br,6-F is a Thalidomide analogue functioning as an E3 ligase activator, promoting the ubiquitination of target proteins for proteolytic degradation. This compound enhances cellular pathways by modulating protein turnover, making it valuable in studies related to protein homeostasis and targeted degradation. Its unique structural features allow for potential further derivatization through substitution at the fluorine or bromine positions, offering avenues for the development of novel reagents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2803445-69-2 |
| Applications | E3 Ligase Activator |
| Formula | C13H8BrFN2O4 |
| Molecular Weight | 355.12 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(F)C(Br)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.