Fig. 1 · Structure
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Thalidomide-5-CH2-NH2 hydrochloride
E3 Ligand of PROTAC
Thalidomide-5-CH2-NH2 hydrochloride serves as an E3 ligase ligand targeting cereblon (CRBN) for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective recruitment of CRBN to ubiquitin-proteasome pathways, promoting the degradation of specific target proteins. Its application is pivotal in targeted protein degradation studies and drug discovery processes aimed at modulating protein levels in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1010100-22-7 |
| Applications | E3 Ligand of PROTAC |
| Formula | C14H14ClN3O4 |
| Molecular Weight | 323.73 |
| SMILES | NCC1=CC(C(N(C2C(NC(CC2)=O)=O)C3=O)=O)=C3C=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.