Fig. 1 · Structure
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Thalidomide-5-COOH
Ligand for E3 Ligase
Thalidomide-5-COOH serves as a ligand for cereblon (CRBN), functioning through its interaction with the E3 ubiquitin ligase complex. This compound is instrumental in the development of PROTACs, enabling targeted protein degradation for potential therapeutic applications. Its role in bridging target proteins for ubiquitination makes it a valuable reagent in chemical biology and drug discovery research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1216805-11-6 |
| Applications | Ligand for E3 Ligase |
| Formula | C14H10N2O6 |
| Molecular Weight | 302.24 |
| SMILES | O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.