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Thalidomide-5-NH-CH2-COO(t-Bu)

Ligands for E3 Ligase

Thalidomide-5-NH-CH2-COO(t-Bu) serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). This derivative of Thalidomide features a t-Bu protecting group, which can be removed under acidic conditions, facilitating the development of proteolysis-targeting chimeras (PROTACs). Thalidomide-5-NH-CH2-COO(t-Bu) is crucial for synthesizing CRBN-based PROTACs, enabling targeted protein degradation for various biological research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2412056-28-9
Applications	Ligands for E3 Ligase
Formula	C₁₉H₂₁N₃O₆
Molecular Weight	387.39
SMILES	O=C(OC(C)(C)C)CNC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.