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Thalidomide-5-NH-PEG2-NH2 hydrochloride

Ligand for E3 Ligase

Thalidomide-5-NH-PEG2-NH2 hydrochloride serves as a ligand for E3 ligase, specifically targeting cereblon (CRBN) proteins. This compound facilitates the formation of PROTAC molecules by linking to a target protein, thereby promoting targeted protein degradation. Its applications extend to the study of protein modulation and degradation pathways in various cellular contexts, enhancing research in drug development and therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2357110-58-6
Applications	Ligand for E3 Ligase
Formula	C₁₉H₂₅ClN₄O₆
Molecular Weight	440.88
SMILES	O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCN)C=C3C2=O)=O)=O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.