Fig. 1 · Structure
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Thalidomide-5-O-C2-NH2 hydrochloride
Ligand for E3 Ligase
Thalidomide-5-O-C2-NH2 hydrochloride is a ligand that targets cereblon, an E3 ubiquitin ligase, facilitating the recruitment of CRBN protein. This compound serves as an essential component in the development of PROTACs (proteolysis-targeting chimeras), enabling selective degradation of target proteins. Its unique mechanism allows researchers to explore the therapeutic potential of targeted protein degradation in various biological contexts, including cancer and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2694727-89-2 |
| Applications | Ligand for E3 Ligase |
| Formula | C15H16ClN3O5 |
| Molecular Weight | 353.76 |
| SMILES | O=C(CCC1N2C(C(C=CC(OCCN)=C3)=C3C2=O)=O)NC1=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.