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Thalidomide-5-O-CH2-COO(t-Bu)

Ligands for E3 Ligase

Thalidomide-5-O-CH2-COO(t-Bu) is a thalidomide derivative that functions as a ligand for cereblon (CRBN), facilitating the recruitment of the CRBN protein. The tert-butyl protecting group can be cleaved under acidic conditions, enabling its use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical intermediate in the development of CRBN-based PROTAC molecules for targeted protein degradation research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2682112-10-1
Applications	Ligands for E3 Ligase
Formula	C₁₉H₂₀N₂O₇
Molecular Weight	388.37
SMILES	O=C(OC(C)(C)C)COC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.