Fig. 1 · Structure
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Thalidomide-5-OH
Ligands for E3 Ligase
Thalidomide-5-OH is an E3 ligase ligand that specifically targets the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras) by linking it to another ligand. Thalidomide-5-OH is utilized in research applications focusing on targeted protein degradation and therapeutic development for various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 64567-60-8 |
| Applications | Ligands for E3 Ligase |
| Formula | C13H10N2O5 |
| Molecular Weight | 274.23 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.