Fig. 1 · Structure
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Thalidomide-5-PEG2-Cl
Ligand for E3 Ligase
Thalidomide-5-PEG2-Cl is a Thalidomide-derived ligand specifically targeting cereblon (CRBN), facilitating the recruitment of this E3 ligase. It is instrumental in the design and synthesis of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. This reagent is valuable in elucidating CRBN-mediated pathways and exploring therapeutic avenues in cancer and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2230956-57-5 |
| Applications | Ligand for E3 Ligase |
| Formula | C17H17ClN2O6 |
| Molecular Weight | 380.78 |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC=C(C=C3C2=O)OCCOCCCl)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.