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Thalidomide-5-PEG2-NH2 hydrochloride

Ligand for E3 Ligase

Thalidomide-5-PEG2-NH2 hydrochloride is a Thalidomide-derived ligand targeting cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively facilitates the recruitment of CRBN for targeted protein degradation applications. It can be conjugated to other ligands via a linker, making it suitable for the development of PROTACs (proteolysis-targeting chimeras) to study protein function and regulation in various biological contexts.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2761406-70-4
Applications	Ligand for E3 Ligase
Formula	C₁₇H₂₀ClN₃O₆
Molecular Weight	397.81
SMILES	O=C1C(N2C(C3=C(C2=O)C=CC(OCCOCCN)=C3)=O)CCC(N1)=O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.