Fig. 1 · Structure
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Thalidomide-5-propoxyethanamine
E3 Ligase Ligand
Thalidomide-5-propoxyethanamine is an E3 ligase ligand specifically designed to target cereblon (CRBN). This compound enhances the recruitment of the CRBN protein, playing a crucial role in modulating protein homeostasis and ubiquitin-proteasome pathways. It is useful for research applications involving targeted protein degradation and the study of CRBN-related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2357107-60-7 |
| Applications | E3 Ligase Ligand |
| Formula | C18H21N3O5 |
| Molecular Weight | 359.38 |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC=C(CCCOCCN)C=C3C2=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.