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Thalidomide-benzo

Ligand for E3 Ligase

Thalidomide-benzo is a Thalidomide-derived ligand specifically designed for the recruitment of the E3 ligase protein cereblon (CRBN). This compound plays a crucial role in the formation of PROTACs (Proteolysis Targeting Chimeras) by enabling targeted degradation of specific proteins. Its application extends to research in cellular models to investigate protein degradation mechanisms and therapeutic strategies in oncology and other diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	458151-34-3
Applications	Ligand for E3 Ligase
Formula	C₁₇H₁₂N₂O₄
Molecular Weight	308.29
SMILES	O=C1NC(C(CC1)N2C(C3=CC4=C(C=C3C2=O)C=CC=C4)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.