Fig. 1 · Structure
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Thalidomide-NH-C10-NH2 hydrochloride
Ligand for E3 Ligase
Thalidomide-NH-C10-NH2 hydrochloride serves as a ligand for the E3 ligase cereblon (CRBN), facilitating targeted protein degradation. This compound enables the recruitment of CRBN to specific proteins through a linker, making it a valuable component in the design of PROTACs. Its application in research includes investigating protein homeostasis and therapeutic strategies for various diseases, including cancer and autoimmune disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2460022-53-9 |
| Applications | Ligand for E3 Ligase |
| Formula | C23H33ClN4O4 |
| Molecular Weight | 464.99 |
| SMILES | O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCCCCCCCCCN)=CC=C3)=O)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.