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Thalidomide-NH-(CH2)3-NH-Boc

Ligands for E3 Ligase

Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified thalidomide that serves as a ligand for cereblon (CRBN), facilitating the recruitment of CRBN protein within cellular systems. The Boc protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC (proteolysis-targeting chimeras) molecules. This compound plays a crucial role as an intermediate for synthesizing CRBN-based designed PROTACs, particularly those targeting 11β-substituted estradiol, making it valuable for research in targeted protein degradation and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2093386-36-6
Applications	Ligands for E3 Ligase
Formula	C₂₁H₂₆N₄O₆
Molecular Weight	430.45
SMILES	O=C(OC(C)(C)C)NCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.