Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified thalidomide that serves as a ligand for cereblon (CRBN), facilitating the recruitment of CRBN protein within cellular systems. The Boc protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC (proteolysis-targeting chimeras) molecules. This compound plays a crucial role as an intermediate for synthesizing CRBN-based designed PROTACs, particularly those targeting 11β-substituted estradiol, making it valuable for research in targeted protein degradation and therapeutic development.
Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified thalidomide that serves as a ligand for cereblon (CRBN), facilitating the recruitment of CRBN protein within cellular systems. The Boc protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC (proteolysis-targeting chimeras) molecules. This compound plays a crucial role as an intermediate for synthesizing CRBN-based designed PROTACs, particularly those targeting 11β-substituted estradiol, making it valuable for research in targeted protein degradation and therapeutic development.
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