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Thalidomide-NH-CH2-COO(t-Bu)

E3 Ubiquitin Ligase

Thalidomide-NH-CH2-COO(t-Bu) is a ligand targeting E3 ubiquitin ligase, specifically utilized in the context of PROTAC BET Degrader-1. This compound exhibits potent biological activity by facilitating the ubiquitination and subsequent degradation of target proteins, making it valuable in research applications focused on protein regulation and targeted protein degradation pathways. Its role in E3 ligase modulation supports investigations into therapeutic interventions for various diseases, including cancer and neurodegenerative disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2093386-23-1
Applications	E3 Ubiquitin Ligase
Formula	C₁₉H₂₁N₃O₆
Molecular Weight	387.39
SMILES	O=C(OC(C)(C)C)CNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.