Fig. 1 · Structure
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Thalidomide-NH-CH2-COOH TFA
E3 Ligase Ligand
Thalidomide-NH-CH2-COOH TFA is a thalidomide-derived ligand targeting the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it a valuable tool in the design of PROTACs for targeted protein degradation research. Its application in the development of bifunctional molecules allows for enhanced modulation of protein levels and contributes significantly to the study of protein homeostasis and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2377032-39-6 |
| Applications | E3 Ligase Ligand |
| Formula | C17H14F3N3O8 |
| Molecular Weight | 445.30 |
| SMILES | O=C(O)CNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(C(F)(F)F)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.