Fig. 1 · Structure
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Thalidomide-O-C8-COOH
Ligands for E3 Ligase
Thalidomide-O-C8-COOH is a Thalidomide-derived ligand targeting the E3 ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN protein, serving as a vital component for the development of Proteolysis Targeting Chimeras (PROTACs). Its unique structure allows for the effective conjugation with other ligands, enabling targeted protein degradation, making it an essential tool in chemical biology and therapeutic research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2225148-51-4 |
| Applications | Ligands for E3 Ligase |
| Formula | C22H26N2O7 |
| Molecular Weight | 430.45 |
| SMILES | O=C(O)CCCCCCCCOC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.