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Thalidomide-O-COOH

Name: Thalidomide-O-COOH
Brand: Adooq Bioscience
SKU: A20247
Availability: InStock

Cat. No. A20247 CAS 1061605-21-7

Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein.

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Biological Activity

Target & Activity

Target	Activity	Value
Cereblon

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HEK293	EC50	> 50 μM	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay	[PMID: 35859867]
HEK293	IC50	> 50 μM	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay	[PMID: 35859867]
HEK293	IC50	0.83 μM	Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay	[PMID: 35859867]

Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1061605-21-7
Formula	C₁₅H₁₂N₂O₇
Molecular Weight	332.26
Synonyms	Cereblon ligand 3; E3 ligase Ligand 3
SMILES	O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	61 mg/mL (183.58 mM)
Water	Insoluble
Ethanol	Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Thalidomide-O-COOH

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DMSO Solution