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Thalidomide-OH

Name: Thalidomide-OH
Brand: Adooq Bioscience
SKU: A20259
Availability: InStock

Cat. No. A20259 CAS 5054-59-1

Thalidomide-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.

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Biological Activity

Target & Activity

Target	Activity	Value
Cereblon

Cellular Effect

Cell Line	Activity	Value	Description	Reference
NAMALVA	IC50	> 1 μM	Antiproliferative activity against human NAMALWA cells assessed as inhibition of [3H]thymidine incorporation after 72 hrs by scintillation counting	[PMID: 23168019]
PBMC	IC50	> 1 μM	Inhibition of TNF-alpha production in LPS-stimulated human PBMC preincubated for 1 hr before LPS challenge measured after 28 to 20 hrs by ELISA	[PMID: 23168019]
T-cell	EC50	> 1 μM	Inhibition of IL-2 production in human T cells measured after 2 to 3 days by ELISA	[PMID: 23168019]

Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	5054-59-1
Formula	C₁₃H₁₀N₂O₅
Molecular Weight	274.23
Synonyms	Cereblon ligand 2; E3 ligase Ligand 2
SMILES	OC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.